Serological Profile of Hepatitis B Virus at Ibn Rochd University Hospital Center (Casablanca, Morocco)
Asian Journal of Immunology, Volume 6, Issue 1,
Page 63-68
Abstract
Aim: Hepatitis B virus (HBV) infection is a major public health problem with complications of progression to cirrhosis and hepatocellular carcinoma. In Morocco, the real extent of the problem related to these infections in the general population is not precisely known.
The objective of our study is to determine the serological profile of hepatitis B in patients referred to the sero-immunology laboratory of Ibn Rochd University Hospital Center in Casablanca.
Study Design: Retrospective study.
Place and Duration of Study: Sero-immunology laboratory at Ibn Rochd University Hospital Center, between January 1st, 2020 to December 31st, 2022.
Methodology: This is a study based on the exploitation of data from the computer system including the results of serum analyses of HBs antigen (HBsAg), HBc antibody (HBcAb) and HBs antibody (HBsAb). The various assays were performed using the chemiluminescence technique on the Architect i1000 Analyser.
Results: Out of 4717 tests collected, 2487 patients (52.70%) were female and 2230 were male (47.30%).Nintypersons were HBsAg positive (1.90%), 846 persons were HBcAb positive (17.91%), 1290 persons were HBsAb positive (27.22%).The distribution of the positivity and negativity of the 3 associated markers showed 3153 persons with all 3 markers negative (67%), 708 persons with only HBsAb positive (15%), 578 persons with HBs Ab as well as HBcAb positive (12.14%), 185 persons with only HBcAb positive (4%) and 90 persons with both HBsAg and HBcAb positive (1.90%).
Conclusion: The prevalence of Hepatitis B in our study population is low and 66.79% remain free of contact with the virus and require vaccination to avoid serious complications of HBV infection.
- Hepatitis B virus
- HBsAg
- HBsAb
- HBcAb
- vaccination
How to Cite
References
Muszlak M, Lartigau-Roussin C, Farthouat L, et al. Vaccination of children against hepatitis B in Mayotte, French island of Comoros. Arch Pediatr 2007;14:1132–6. French
Pierre Tiollais M, Chen Zhu M. The hepatitis B. Pathol Biol. 2010;58:243–4.
World Health Organization, Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection; 2015. Available:https://www.who.int/publications/i/item/9789241549059
Accessed February 28, 2020.
WHO Geneva. Introduction of hepatitis B vaccine in childhood immunization services. WHO; 2002. English Available:http://www.who.int/vaccines-documents/
Accessed May 2, 2020.
Michel ML, Tiollais P. Hepatitis B vaccines: Protective efficacy and therapeutic potential. Pathol Biol. 2010;58:288–95.
Alter Miriam J. Epidemiology of viral hepatitis and HIV co-infection. J Hepatol 2006;44:6–9.
Bristol-Myers S. Hepatitis B: Knowing it better to treat it better. J Pediatr Pueric 2006;19:340–3. French
Hou J, Liu Z, Gu F. Epidemiology and prevention of hepatitis B virus infection. Int J Med Sci. 2005;2:50–7.
Read JS, Cannon MJ, Stanberry LR, Schuval S. Prevention of mother-to-child transmission of viral infections. Curr Probl Pediatr Adolesc Health Care. 2008;38: 274–97.
Pawlotsky J-M. Virological techniques for the diagnosis and monitoring of hepatitis B. Clinical and Biological Gastroenterology. 2008;32(1):S56–63.
French
Sbai A, Baha W, Ougabrai H, Allalia T, Dersi N, Lazaar F, et al. Prevalence of hepatitis B virus infection and assessment of risk factors in Morocco. Pathology Biology. 2012;60(5):e65–9. French
Baha W, Foullous A, Dersi N, They-they TP, El alaoui K, Nourichafi N, et al. Prevalence and risk factors of hepatitis B and C virus infections among the general population and blood donors in Morocco. BMC Public Health. 2013;13(1):50–8.
Adouani B, Alami R, Laouina A, et al. Hepatitis B in the population of blood donors in Morocco: comparison of the prevalence of HBsAg in the different categories of donors. Transfus Clin Biol. 2013;3(20):305–6. French
Laouina A, Adouani B, Alami R, Prevalence of infectious markers transmissible by transfusion among blood donors at the CRTS in Rabat (Morocco). Transfer Clin Biol. 2016;23(4):309–10.
French
Feindiria M, Prevalence of hepatitis B Virus infection markers among patients of the Ibn Sina University Hospital Center (Rabat, Morocco): Intervirology. 2022; 65(2):80–86.
Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Estimates of worldwide Prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013. Lancet. 2015;386(10003):1546–55.
Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccinated. 2012;30(12): 2212–9.
Diop M. Prevalence of hepatitis B surface antigen and its associated factors in Senegalese military personnel sent on mission to Darfur. Pan Afr. Med. J. 2017; 26:154.
Barkat A, Braikat M, Lamdouar Bouazzaoui N. National Vaccination Schedule: Evolution and perspectives. Santé Maghreb; 2008. French Available:http://www.abhatoo.net.ma/maalama-textuelle/developpement-economique-et-social/developpement-social/sante/sante-publique/calendrier-national-de-vaccination-evolution-et-perspectives
Accessed on March 02, 2022.
Moroccan Ministry of Health, National Viral Hepatitis Seroprevalence Survey; 2019.
French Available:https://www.sante.gov.ma/Publications/Etudes_enquete/Documents/2022/Brochure_Etude-HV_VF.pdf
Accessed April 28, 2020.
Ministry of Health and Social Protection of Morocco, National strategic plan for the fight against viral hepatitis, 2022-2026. French Available:https://www.sante.gov.ma/ActivitesImages/PLAN%20STRAT%C3%89GIQUE%20NATIONAL%20DE%20LUTTE%20CONTRE%20LES%20H%C3%89PATITES%20VIRALES%202022-2026.pdf
Accessed on January 15, 2023.
Karimi G, Zadsar M, Vafaei N, et al. Prevalence of antibody to Hepatitis B core antigen and Hepatitis Bvirus DNA in HBsAg negative healthy blood donors. Virol J. 2016;13(1):36–6.
Cuadrado A, Perelló C, Cabezas J, Llerena S, et al. Update on epidemiology of hepatitis B in a low-endemic European country: there is still much to do. J Viral Hepat. 2020;27(11):1261–5.
Ogunfemi MK, Olawumi HO, Olokoba AB et al. Prevalence of antibody to hepatitis B core antigen among hepatitis B surface antigen-negative blood donors in Ilorin, Nigeria: A Cross Sectional Study. Malawi Med J. 2017;29(1):32–6.
Mansour W, Malick FZ, Sidiya et al. Prevalence, risk factors, and molecular epidemiology of hepatitis B and hepatitis delta virus in pregnant women and in patients in Mauritania. J Med Virol. 2012; 84(8):1186–98.
-
Abstract View: 0 times
PDF Download: 0 times
