Antibiotic Susceptibility Patterns and Bacteriological Profile of Catheter-Associated Urinary Tract Infections in a Tertiary Care Hospital in Bangladesh: A Cross-Sectional Study
Asian Journal of Immunology, Volume 6, Issue 1,
Page 85-92
Abstract
Aim and Objective: This study aimed to analyze the bacteriological profile of catheter-associated urinary tract infections (CAUTI) and their antibiotic susceptibility patterns in a tertiary care hospital in Bangladesh to inform appropriate treatment guidelines and help reduce the development of multi-drug resistance among organisms.
Materials and Methods: A cross-sectional study was conducted from June 2021 to December 2022, involving 694 urine samples from catheterized patients. Samples were processed and inoculated on Cystine Lactose Electrolyte Deficient (CLED) agar, and bacterial etiological agents were identified. Antibiotic susceptibility testing was performed using the Modified Kirby-Bauer Disk Diffusion method, following Clinical and Laboratory Standards Institute (CLSI) 2022 - M100 guidelines.
Results: The study found varying susceptibility patterns across different antibiotic classes, with higher resistance rates for Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli compared to some previous research. Amikacin showed the highest susceptibility rate among aminoglycosides (31.2%), while colistin had the highest susceptibility rate in the polymyxin class (85.7%). Organism-wise susceptibility patterns indicated statistically significant differences in resistance patterns for Pseudomonas aeruginosa and Escherichia coli across various antibiotic classes.
Conclusion: Our findings underscore the urgent need for continuous surveillance and monitoring of antibiotic resistance patterns and the development of new strategies to combat antibiotic-resistant bacteria. The data provided in this study will aid clinicians in selecting appropriate antimicrobial therapy for catheter-associated urinary tract infections caused by the isolated pathogens, ultimately contributing to the reduction of multi-drug resistance among organisms.
- Catheter-Associated Urinary Tract Infections (CAUTI)
- antibiotic resistance
- Modified Kirby-Bauer Disk Diffusion method
- Bangladesh
How to Cite
References
Munshi R, Kanitkar M. Bacteriological profile of catheter-associated urinary tract infection in a tertiary care hospital in Western India. Journal of Family Medicine and Primary Care. 2022;11(2):685-688.
World Health Organization. Antimicrobial resistance: Global report on surveillance; 2018
United Nations. Global action plan on antimicrobial resistance; 2016
Centers for Disease Control and Prevention. Healthcare-associated infections; 2021
Dudeck MA, Edwards JR, Allen-Bridson K, Gross C, Malpiedi PJ, Peterson, KD, Sievert DM. National Healthcare Safety Network report, data summary for, Device-associated module. American Journal of Infection Control. 2013;41(12):1148-1166.
Darouiche RO. Device-associated infections: A macroproblem that starts with microadherence. Clinical Infectious Diseases. 2004;39(3):345-349.
Centers for Disease Control. Catheter-Associated Urinary Tract Infections; 2014. [Online] Available:https://www.cdc.gov/hai/ca_uti/uti.html. [Accessed March 2023].
Centers for Disease Control. General Key Terms; 2020 [online] Available:Available:https://www.cdc.gov/nhsn/pdfs/pscmanual/16psckeyterms_current.pdf [Accessed March 2023].
Tille P. Bailey & Scott's diagnostic microbiology-e-book. Elsevier Health Sciences. 2015.
CLSI. Performance Standards for Antimicrobial Susceptibility Testing 32nd ed. CLSI supplement M100. Wayne PA: clinical and laboratory standards institute; 2022.
Collee GJ, Marimon BP, Frazer AG, Simmons A. Makie McCartney Practical Medical Microbiology. Collee JG, 14ed; 11:245-258,4:151-177.
Kulkarni AP, Agnihotri SA., Kulkarni SP. Antibiotic susceptibility patterns of bacterial isolates from pus samples in a tertiary care hospital of Pune, India. Journal of Clinical and Diagnostic Research. 2014;8(7): DC08-DC11.
Kazi M, Drego L., Nikam C, Ajbani K, Soman R. Evaluation of the E test for susceptibility testing of extensively drug-resistant isolates of Mycobacterium tuberculosis. Journal of Clinical Microbiology. 2015;53(4):1329-1331.
Tomar L, Kaur T, Anand KB, Radhakrishnan G. Susceptibility pattern of gram-negative bacilli to antimicrobial agents: Is there a difference between surgical and medical intensive care units? Indian Journal of Critical Care Medicine. 2017;21(2):78-83.
Singh AK, Das S, Singh S, Gajamer VR, Pradhan N. Antimicrobial susceptibility pattern of bacterial isolates from wound infection in the eastern development region, Nepal. BMC Research Notes. 2018;11(1):1-6.
Liu P, Li X, Luo M., Xu X, Su K, Chen S. Qin X. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection/colonization and predictors of mortality: A retrospective study. Pathogens and Global Health. 2020;114(1):37-45.
Khadim T. Antimicrobial susceptibility patterns of bacterial isolates from urinary tract infections at a tertiary care hospital. Journal of Clinical and Experimental Investigations. 2021;12(1): em00756.
-
Abstract View: 2 times
PDF Download: 0 times