Asian Journal of Immunology http://journalaji.com/index.php/AJI <p style="text-align: justify;"><strong>Asian Journal of&nbsp;Immunology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJI/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of the immune system in all organisms. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;"><img src="/public/site/images/sciencedomain/free-sign.gif" width="69" height="28"></p> <p style="text-align: justify;"><strong>Publication Charge: FREE</strong>. All the manuscripts submitted within this month will be published free of cost. There is no publication charge for this month.&nbsp;</p> Asian Journal of Immunology en-US Asian Journal of Immunology Local Immunity Concept in the Context of the Novel Corona Viral Infection: A Consideration http://journalaji.com/index.php/AJI/article/view/30109 <p>The pandemic of novel corona virus disease (covid 19), is presently sweeping the world over. The causative virus is named, SARS-CoV-2. The rapidity with which the pandemic is advancing is catastrophic. That there is no known treatment for this killer disease is throwing public at large into a state of fear psychosis. The urgent need for preventive vaccine is felt now, more than ever before Though promising research is going on, the goal to achieve a breakthrough vaccine is still a long way to go. Since SARS-CoV-2 is an infection restricted to respiratory system of the affected, vaccines aimed at inducing local (mucosal) immunity may offer better chance of preventing the acquisition and spread of the disease to others, than induction of systemic immunity. With this background theme, this article briefly reviewed the epidemiology, the vaccine trials of the Covid 19 as well as the immune responses to viral infection in general and with a special focus on the concept of Local immunity advanced by Prof Besredka (1924). The historical perspective of the local immunity concept is recapitulated and the diseases, both viral and bacterial, to which vaccines are developed in the past basing on this concept are reviewed. A case is made out for applying this concept for the prevention of covid 19. It is suggested that an approach to boost local immunity, than systemic immunity, might be a better strategy of prevention of covid 19.</p> A. S. V. Prasad ##submission.copyrightStatement## 2020-04-01 2020-04-01 16 25 Immunomodulatory Potentials of Probiotics: A Review http://journalaji.com/index.php/AJI/article/view/30108 <p>In recent years, research has focused on natural mechanisms for the management, treatment, and curing of human infections and diseases. One of such natural methods is the application of probiotics, which are live microorganisms which when administered in adequate amounts confer a health benefit on the host. The beneficial effects associated with probiotics were originally thought to be a result of improvements in the intestinal microbial balance, however, there are shred evidence that probiotics can also provide benefits by modulating the immune functions. The ability of these probiotics, majorly the <em>Lactobacillus</em> and <em>Bifidobacterium</em> species to boost the immune system is proposed to be a result of their interactions with the cells of the immune system. They have been reported to stimulate various parts of the immune system, through several mechanisms enhancing their functions. It has also been established that the effects of probiotic bacteria may also result from soluble factors from these microbes that alter epithelial permeability or mediate activation, maturation or survival of dendritic cells, B and T-cells. Probiotic bacteria, their cell wall components, and other stimulating molecules have been shown to have significant effects on the functionality of the immune systems through the activation of multiple immune mechanisms. This study is aimed at describing the immunological mechanisms of probiotics and their beneficial effects on the host immune system.</p> David Chinemerem Nwobodo Malachy Chigozie Ugwu ##submission.copyrightStatement## 2020-03-31 2020-03-31 1 15