Main Article Content
Background: Traditional preparation of the leaf of Flemingia stricta (Fabaceae) Roxb. , a medicinal plant of the Indian subcontinent, has been used for the treatment of different diseases as a herbal preparation. Our purpose was to analyze the neuropharmacological effects of different chemical extracts of Flemingia stricta Roxb. in mice.
Methods: In present study, the anxiogenic activity of crude extracts of Flemingia stricta leaves was determined using standard animal behavioral models, such as hole cross and open field; Sedative and anxiolytic potential were evaluated by performing thiopental sodium induced sleeping times tests and elevated plus maze test respectively.
Results: The crude extracts at the doses of 200 and 400mg/Kg exhibited a significant dose-dependent suppression of movement of mice in both open field and hole cross test. In the anxiolytic and sedative study, extracts displayed an increased percentage of entry of mice into open arm at both doses which are 200 and 400mg/Kg. Plant extracts produced a significant increase in sleeping duration and reduction of onset of sleep compared to control at the both doses of 200 and 400 mg/Kg.
Conclusion: This study clearly showed that the treated extracts have promising anxiolytic and sedative effect. Further studies on the prime constituent of this plant extract may provide lead compound in future.
Buller R, Legrand V. Novel treatments for anxiety and depression: Hurdles in bringing them to the market. Drug Discov Today. 2001;6:1220-1230.
Yadav AV, Kawale LA, Nade VS. Effect of Morus alba L. (mulberry) leaves on anxiety in mice. Indian J Pharmacol. 2008;40:32-36.
Titov N, Andrews G, Kemp A, Robinson E. Characteristics of adults with anxiety or depression treated at an internet clinic: comparison with a national survey and an outpatient clinic. PLOS ONE. 2010;5(5): e10885.
Katzung B: Basic and clinical pharmacology. 6th ed. California: Prentice-Hall International In. 1994;323.
Rabbani M, Sajjadi SE, Mohammadi A. Evaluation of the anxiolytic effect of Nepeta persica Boiss. in mice. Evid-Based Complement Alternat Med. 2008;5(2):181-186.
Rang HP, Dale MM, Ritter JM: Pharmacology. 3rd ed. London: Churchill Livingstone Inc. 1996;512.
Clark WG, Brater DC, Johnscn AR. Goth’s medical pharmacology. 12th ed. New Delhi: Galgotia Publication Pvt. Ltd. 1989;288.
Essig CF. Addiction to nonbarbiturate sedative and tranquilizing drug. Clin Pharmacol Ther. 1964;5:334-343.
Isbell H, Fraser HF. Addiction to analgesics and barbiturates. J Pharmacol Exp Ther. 1950;99(4:2):355-397.
O’Brien CP. Drug addiction and drug abuse. In: Brunton L, Chabner B, Knollman B, editors. Goodman and Gilman’s the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill Professional. 1996;570.
Tripathi KD. Essential medical pharmacology. 3rd ed. New Delhi: Jaypee Brothers Medical Publishers. 1994; 324.
Schuckit MA. A low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry. 1994;151:184-189.
Hook f. Flemingia stricta Roxb. Fl Ind 1832;3:342.
Motaleb MA, Hossain MK, Alam MK, Mamun MA, Sultana M. Commonly used medicinal herbs and shrubs by traditional herbal practitioners Glimpses from Thanchi Upazila of Bandarban. 88-89.
Rahman MA, Uddin SB, Wilcock CC. Medicinal plants used by Chakma tribe in Hill Tracts Districts of Bangladesh. Indian Journal of Traditional Knowledge. 2007;6 (3):508-517.
Uddin SN. Traditional Uses of Ethno-medicinal Plants of the Chittagong Hill Tracts. Bangladesh National Herbarium, Bangladesh. 2006;992.
Khisha T, Karim R, Chowdhury SR, Banoo R. Ethnomedical studies of Chakma communities of chittagong hill tracts, Bangladesh. Bangladesh Pharmaceutical Journal. 2012;15(1):59-67.
Biozid MS, Alam MN, Abeden MJ, Chowdhury AI, Faruk M, Ferdous KU, nitul AI, Rahman MM. Anti-Oxidant Effect of Flemingia stricta Roxb. Leaves Methanolic Extract. European Journal of Biological Research. 2018;8:224-231.
Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: A review. Int Pharm Sci. 2011; 1:98–106.
Gupta BD, Dandiya PC, Gupta ML. A psychopharmacological analysis of behavior in rat. Jpn J Pharmacol. 1971;21: 293.
Takagi K, Watanabe M, Saito H. Studies on the spontaneous movement of animals by the hole cross test; effect of 2-dimethylaminoethanol and its acyl esters on the central nervous system. Jpn J Pharmacol. 1971;21:797-810.
Ferrini R, Miragoli G, Taccardi B. Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class. Arzneim-Forsch (Drug Res). 1974;24:2029-2032.
Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl). 1987;92:180-185.
Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratrory activity in an elevated plus-maze: A novel test if anxiety in rat. Pharmacol Biochem Behav. 1986;24:525-529.
Raquibul Hasan SM, Hossain MM, Akter R, Jamila M, Mazumder EHM, Rahman S. Sedative and anxiolytic effects of different fractions of the Commelina benghalensis Linn. Drug Discov Ther. 2009;3:221-227.
Sen AK, Bose S, Dutta SK. Comparative evaluation of CNS depressant activity of the flavonoid fractions from the fresh leaves and flowers of Ixora coccinea Linn. J Pharma Sci Tech. 2011;1(1):54-56.
Hossain MM, Biva IJ, Jahangir R, Vhuiyan MMI. Central nervous system depressant and analgesic activity of Aphanamixis polystachya (Wall.) parker leaf extract in mice. Afr J Pharm Pharmacol. 2009;3(5): 282-286.
Dhonnchadha BAN, Bourin M, Hascoet M. Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety. Behav Brain Res. 2011;140:203-214.
Sharmen F, Mannan A, Rahman MM, Chowdhury MA, Uddin ME, Ahmed AM. Investigation of in vivo neuro-pharmacological effect of Alpinia nigra leaf extract. Asian Pac J Trop Biomed. 2014; 4(2):137–142.
Khan IN, Sarker MM, Ajrin M. Sedative and anxiolytic effects of ethanolic extract of Calotropis gigantea (Asclepiadaceae) leaves. Asian Pac J Trop Biomed. 2014; 4(Suppl 1):S400–S404.
Griffin CE, Kaye AM, Bueno FR, Kaye AD. Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J. 2013;13(2):214–223.
Gazzaniga M, Ivry R, Mangun G. Cognitive neuroscience: The biology of the mind. New York: W.W. Norton & Company; 2009.
Amnesia. The gale encyclopedia of science. Ed. K. Lee Lerner and Brenda Wilmoth Lerner. 4th ed. Detroit: Gale. Gale Virtual Reference Library. 2008;1:182–184.